P21-adamantane 10mg | 20-Vial Kit | CNTF Nootropic Peptide
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P21-adamantane 10mg | 20-Vial Kit | Adamantane-modified CNTF-derived peptide — hippocampal neurogenesis, BDNF upregulation, and cognitive research. ≥99% HPLC purity, Janoshik COA. Research use only.
* The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgement of your healthcare professional.
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What is P21-adamantane?
P21-adamantane is a modified neurotrophin-mimetic peptide derived from the CNTF (ciliary neurotrophic factor) sequence, with an adamantane moiety attached to enhance blood-brain barrier penetration and receptor engagement. Activates STAT3/JAK signalling and BDNF expression. Studied for hippocampal neurogenesis, cognitive enhancement, and neuroprotection models, with the adamantane modification providing superior CNS bioavailability compared to unmodified P21. Research use only.
Research Applications
Hippocampal Neurogenesis
Dentate gyrus progenitor cell proliferation, BrdU/EdU incorporation, DCX expression
BDNF Upregulation
BDNF mRNA and protein expression, TrkB signalling, CREB phosphorylation
STAT3/JAK Pathway Research
CNTF receptor complex activation, STAT3 nuclear translocation, target gene profiles
Blood-Brain Barrier Penetration
Adamantane moiety CNS uptake vs unmodified peptide — pharmacokinetic comparison
Cognitive & Memory Research
Morris water maze, novel object recognition, LTP modulation in rodent models
Quick Specs
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 2411025-13-3 |
| Molecular Formula | Adamantane-AEAEAAAKEAAAKAAE (modified CNTF loop), MW ~2,200 Da |
| Identity | MS molecular weight confirmed — every batch |
| Peptide Type | CNTF-Derived Nootropic / Neurogenic Peptide |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Storage | -20°C sealed | 2–8°C reconstituted (3 weeks) |
| Shelf Life | 24 months (unopened) |
Certificate of Analysis (COA)
Frequently Asked Questions
Frequently asked questions
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Websites in professional use templating systems. Commercial publishing platforms and content management systems ensure that you can show different text, different data using the same template. When it’s about controlling hundreds of articles, product pages for web shops.
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