Retatrutide 100mg | 20-Vial Kit | Triple GIP/GLP-1/Glucagon Agonist | Obesity & Metabolic Research
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Retatrutide (LY3437943 / triple incretin agonist, CAS 2381932-72-3) 100mg — ≥99% HPLC purity, MS confirmed, Janoshik COA. Research use only.
* The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgement of your healthcare professional.
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What is Retatrutide??
Retatrutide (LY3437943, CAS 2381932-72-3) is a 39-amino acid triple-receptor agonist simultaneously activating the GIP receptor (GIPR), GLP-1 receptor (GLP-1R), and glucagon receptor (GCGR) — the first clinically investigated triagonist incretin peptide. Developed by Eli Lilly, it incorporates a C18 fatty diacid moiety for albumin binding, yielding a half-life of approximately 6 days. Phase 2 data demonstrated up to ~24% body weight reduction — exceeding tirzepatide (dual GIP/GLP-1) — primarily attributed to the additive glucagon receptor arm driving hepatic fat oxidation, thermogenesis, and appetite suppression independent of insulin secretion. Retatrutide is the leading research tool for dissecting the individual and combined contributions of all three incretin-related receptor axes.
Research Applications
Triple Receptor Dissection
GIPR vs. GLP-1R vs. GCGR individual arm contributions — selective antagonist co-treatment designs
Obesity & Thermogenesis
GCGR-mediated energy expenditure, brown adipose UCP1, hepatic fat oxidation — beyond dual incretin
Glucose Homeostasis
Triple incretin insulin secretion, glucagon regulation balance, hepatic glucose output at GCGR
NAFLD/NASH Research
Hepatic steatosis, liver fat quantification, fibrosis biomarkers under triple agonism
vs Tirzepatide Comparison
Dual (tirzepatide) vs. triple (retatrutide) incretin: weight loss depth, metabolic breadth, receptor kinetics
Quick Specs
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 2381932-72-3 |
| Also Known As | LY3437943, triple incretin agonist |
| Molecular Weight | ~4681 Da |
| Half-Life | ~6 days (C18 fatty diacid albumin binding) |
| Receptors | GIPR + GLP-1R + GCGR (triple agonist) |
| Peptide Type | Synthetic triple incretin receptor agonist — triagonist |
| Identity | MS molecular weight confirmed — every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Storage | -20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Shelf Life | 24 months unopened |
Certificate of Analysis (COA)
Frequently Asked Questions
Frequently asked questions
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A seemingly elegant design can quickly begin to bloat with unexpected content or break under the weight of actual activity. Fake data can ensure a nice looking layout but it doesn’t reflect what a living, breathing application must endure. Real data does.
Websites in professional use templating systems. Commercial publishing platforms and content management systems ensure that you can show different text, different data using the same template. When it’s about controlling hundreds of articles, product pages for web shops.
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