Orexin B 5mg | 20-Vial Kit | Hypocretin-2 | OX2R Selective Sleep & Arousal Research
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Orexin B 5mg | 20-Vial Kit — Orexin-B (Hypocretin-2) — 28aa linear neuropeptide preferentially activating OX2R over OX1R to regulate sleep-wake transitions and energy homeostasis; studied in arousal and metabolic research. ≥99% HPLC purity, MS confirmed, Janoshik COA. Research use only.
* The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgement of your healthcare professional.
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What is Orexin B??
Orexin B (Hypocretin-2, CAS 205640-91-1) is a 28-amino acid C-terminally amidated linear neuropeptide co-produced with Orexin A from the same prepro-orexin precursor. Sequence: Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2. Unlike Orexin A, Orexin B lacks the N-terminal pyroglutamyl residue and disulfide bridges – giving it a linear, more flexible structure. This structural difference underlies its selective binding to OX2R over OX1R (approximately 5-100-fold preference), making it the ideal pharmacological tool for dissecting OX2R-specific functions from dual OX1R/OX2R effects. OX2R is expressed prominently in the tuberomammillary nucleus (histaminergic arousal) and the dorsal raphe (serotonergic), and OX2R-selective compounds are the mechanistic basis for the insomnia drug suvorexant.
Research Applications
OX2R-Selective Pharmacology
OX2R vs. OX1R selectivity profiling – Gq signalling, receptor internalisation, competitive binding vs. Orexin A
Sleep Architecture & NREM
OX2R role in non-REM sleep stability, histaminergic arousal pathway – TMN activation, REM/NREM balance
Histaminergic Arousal System
Tuberomammillary nucleus OX2R – histamine release, H1 receptor arousal pathway downstream of OX2R activation
Insomnia & Hypersomnia Models
OX2R antagonist comparison (suvorexant), sleep onset, maintenance, receptor occupancy/dose-response studies
Orexin A vs. B Comparison
Selectivity, potency, and functional dissection – identify OX1R-specific (addiction, analgesia) vs. OX2R-specific (sleep, arousal) biology
Quick Specs
| Form | Lyophilized powder |
| Purity | >=99% by HPLC – every batch |
| CAS Number | 205640-91-1 |
| Also Known As | Hypocretin-2, HCRT2 |
| Sequence | Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2 |
| Structure | Linear 28-aa (no disulfide bridges – contrasts with Orexin A) |
| Receptor Selectivity | OX2R-preferring (~5-100x vs. OX1R) – tool for OX2R-specific research |
| Peptide Type | Endogenous 28-aa hypothalamic neuropeptide / OX2R-selective agonist |
| Identity | MS molecular weight confirmed – every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS – Qingdao, China |
| Storage | -20C sealed | 2-8C reconstituted (2-4 weeks) |
| Shelf Life | 24 months unopened |
Certificate of Analysis (COA)
Frequently Asked Questions
Frequently asked questions
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Websites in professional use templating systems. Commercial publishing platforms and content management systems ensure that you can show different text, different data using the same template. When it’s about controlling hundreds of articles, product pages for web shops.
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