PNC-27 5mg | 20-Vial Kit | Anticancer Peptide Kit
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PNC-27 5mg | 20-Vial Kit — p53-derived proapoptotic peptide — penetrates HDM-2-overexpressing cancer cell membranes to trigger membranolytic apoptosis selectively in tumour cells that overexpress HDM-2. ≥99% HPLC purity, MS confirmed, Janoshik COA. Research use only.
* The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgement of your healthcare professional.
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What is PNC-27?
PNC-27 (HDM2-targeting chimeric anticancer peptide) is a 32-amino acid chimeric peptide (HDM2-binding + penetratin). Chimeric peptide combining an HDM2 (human double minute 2)-binding domain with a penetratin cell-penetrating sequence. Proposed mechanism: binds membrane-associated HDM2 overexpressed on cancer cell surfaces, disrupting p53-HDM2 interaction and inducing selective cancer cell membranolysis while sparing normal cells.
Research Applications
HDM2-p53 Disruption
Protein interaction inhibition at MDM2/HDM2-p53 interface
Cancer-Selective Lysis
Membrane-targeted anticancer peptide mechanism research
Cell Penetrating Delivery
Penetratin-mediated intracellular delivery system biology
Cancer vs Normal Cells
Selectivity mechanism — HDM2 overexpression in cancer
vs Small Molecule MDM2i
Comparison with nutlin-3, AMG-232 mechanism and selectivity
Quick Specs
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | Not publicly standardized |
| Molecular Formula | Sequence-dependent (33-amino-acid peptide) |
| Peptide Type | Synthetic Peptide / p53-MDM2 Interaction Inhibitor |
| Identity | MS molecular weight confirmed — every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Storage | -20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Shelf Life | 24 months unopened |
Certificate of Analysis (COA)
Frequently Asked Questions
Frequently asked questions
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