PNC-27 10mg | 20-Vial Kit | 100mg Total | Anticancer Peptide
🌏 China Warehouse
PNC-27 10mg | 20-Vial Kit — p53-derived proapoptotic peptide — penetrates HDM-2-overexpressing cancer cell membranes to trigger membranolytic apoptosis selectively in tumour cells that overexpress HDM-2. ≥99% HPLC purity, MS confirmed, Janoshik COA. Research use only.
* The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgement of your healthcare professional.
{“@context”: “https://schema.org”, “@type”: “FAQPage”, “mainEntity”: [{“@type”: “Question”, “name”: “How do I reconstitute this peptide?”, “acceptedAnswer”: {“@type”: “Answer”, “text”: “Add 1–2mL bacteriostatic water to the lyophilized vial by directing water down the inner wall of the vial. Swirl gently until the powder fully dissolves — do not shake or vortex. The solution should be clear and colourless. Use immediately or refrigerate at 2–8°C.”}}, {“@type”: “Question”, “name”: “How should this peptide be stored?”, “acceptedAnswer”: {“@type”: “Answer”, “text”: “Store lyophilized peptide vials at −20°C for long-term storage. Once reconstituted, store at 2–8°C (refrigerator) and use within 21–28 days. Avoid repeated freeze-thaw cycles, direct light, and heat exposure.”}}, {“@type”: “Question”, “name”: “What purity is this QSC compound and how is it verified?”, “acceptedAnswer”: {“@type”: “Answer”, “text”: “All QSC compounds are tested to ≥99% purity by HPLC peak area analysis on every production batch. Molecular identity is confirmed by mass spectrometry. A Certificate of Analysis (COA) is published on the product page and independently verifiable at verify.janoshik.com using the batch reference number.”}}]}
What is PNC-27 10mg?
PNC-27 is a 32-amino acid chimeric anticancer peptide containing a p53 HDM-2-binding domain fused to a membrane-destabilising penetratin sequence. It binds HDM-2 (human MDM-2) expressed on the plasma membrane of cancer cells — an expression pattern absent in normal cells — inducing selective membranolysis of tumour cells via a pore-forming mechanism. This selectivity makes PNC-27 a highly specific research tool for studying cancer cell membrane disruption and MDM-2-targeted therapy without affecting normal cell viability.
Research Applications
Selective Tumour Cell Lysis Research
PNC-27 lyses cancer cell lines expressing plasma membrane HDM-2 while sparing normal cells. Standard in vitro readouts: LDH release assay, PI exclusion, MTT viability across cancer vs normal cell panels.
MDM-2/p53 Pathway Research
PNC-27 exploits cancer-specific plasma membrane HDM-2 expression — distinct from nuclear MDM-2 p53 degradation. Research into membranous MDM-2 as a cancer-specific target.
Cancer Cell Line Selectivity Profiling
Mapping HDM-2 plasma membrane expression across cancer cell lines to identify PNC-27-responsive tumour types — pancreatic, breast, and melanoma lines show high sensitivity.
Quick Specs
| Product | PNC-27 10mg × 10 Vials (100mg total) |
| Mechanism | HDM-2 binding + membranolysis |
| Format | Lyophilised powder, 10-vial kit |
| Purity | ≥99% HPLC, MS confirmed |
| Storage | −20°C lyophilised; 4°C reconstituted |
Certificate of Analysis (COA)
Frequently Asked Questions
Frequently asked questions
A seemingly elegant design can quickly begin to bloat with unexpected content or break under the weight of actual activity. Fake data can ensure a nice looking layout but it doesn’t reflect what a living, breathing application must endure. Real data does.
Websites in professional use templating systems. Commercial publishing platforms and content management systems ensure that you can show different text, different data using the same template. When it’s about controlling hundreds of articles, product pages for web shops.
A seemingly elegant design can quickly begin to bloat with unexpected content or break under the weight of actual activity. Fake data can ensure a nice looking layout but it doesn’t reflect what a living, breathing application must endure. Real data does.
Websites in professional use templating systems. Commercial publishing platforms and content management systems ensure that you can show different text, different data using the same template. When it’s about controlling hundreds of articles, product pages for web shops.
Reviews
Clear filtersThere are no reviews yet.