ARA-290 10mg | 20-Vial Kit | 200mg total | Cibinetide
🇪🇺🇬🇧🇺🇸🇨🇦 4-Region Domestic Shipping
QSC ARA-290 (Cibinetide) — innate repair receptor (IRR) agonist, EPO helix B peptide. ≥99% HPLC purity, MS confirmed, Janoshik COA. Research use only.
$370.00
* The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgement of your healthcare professional.
{“@context”: “https://schema.org”, “@type”: “FAQPage”, “mainEntity”: [{“@type”: “Question”, “name”: “How do I reconstitute this peptide?”, “acceptedAnswer”: {“@type”: “Answer”, “text”: “Add 1–2mL bacteriostatic water to the lyophilized vial by directing water down the inner wall of the vial. Swirl gently until the powder fully dissolves — do not shake or vortex. The solution should be clear and colourless. Use immediately or refrigerate at 2–8°C.”}}, {“@type”: “Question”, “name”: “How should this peptide be stored?”, “acceptedAnswer”: {“@type”: “Answer”, “text”: “Store lyophilized peptide vials at −20°C for long-term storage. Once reconstituted, store at 2–8°C (refrigerator) and use within 21–28 days. Avoid repeated freeze-thaw cycles, direct light, and heat exposure.”}}, {“@type”: “Question”, “name”: “What purity is this QSC compound and how is it verified?”, “acceptedAnswer”: {“@type”: “Answer”, “text”: “All QSC compounds are tested to ≥99% purity by HPLC peak area analysis on every production batch. Molecular identity is confirmed by mass spectrometry. A Certificate of Analysis (COA) is published on the product page and independently verifiable at verify.janoshik.com using the batch reference number.”}}]}
What is ARA-290?
ARA-290 (Cibinetide) is an 11-amino acid synthetic peptide derived from the helix B surface peptide (HBSP) of erythropoietin (EPO). Unlike EPO itself, ARA-290 selectively activates the innate repair receptor (IRR) — a heterodimeric complex of the EPO receptor and the beta common receptor (βcR) — without engaging the classical homodimeric EPO receptor responsible for erythropoiesis. This separation of tissue-protective signalling from haematopoietic activity makes ARA-290 a focused research tool for studying EPO’s non-erythroid cytoprotective and anti-inflammatory properties.
Research Applications
Mechanism of Action
ARA-290 binds the IRR (a heterodimer of EPO receptor subunit + βcR subunit), triggering a distinct intracellular signalling cascade from classical EPO. Downstream activates PI3K/Akt (cell survival), JAK2/STAT3 (anti-apoptotic gene expression), and MAPK/ERK (cell proliferation) pathways. Critically, does not activate the EPOR homodimer, so does not stimulate erythropoiesis, haemoglobin synthesis, or platelet aggregation risk associated with exogenous EPO administration.
Key Research Data
| Phase 2 RCT (Sarcoidosis SFN) | N=55; ARA-290 4mg SC × 28 days vs placebo. Primary endpoint: corneal nerve fibre density (CNFD). Result: significant CNFD preservation + pain NRS reduction (p<0.05) |
| Pancreatic islet study | Human islets treated with IL-1β + IFN-γ; ARA-290 rescued GSIS, reduced apoptosis markers (caspase-3), reduced TNF-α secretion |
| Rodent ischaemia model | ARA-290 SC pre-treatment reduced renal tubular injury scores 40-60% vs vehicle in I/R models (rat) |
| Selectivity vs EPO | No haematopoietic effect confirmed across multiple studies: haematocrit, haemoglobin, reticulocyte count unchanged at research doses |
Quick Specs
| Compound | ARA-290 (Cibinetide) |
| Sequence | QEQLERALNSS (11 amino acids, helix B surface peptide of EPO) |
| Molecular Formula | C₅₄H₈₈N₁₄O₁₉ |
| Molecular Weight | ~1,277.4 Da |
| CAS Number | 866395-18-8 |
| Format | Lyophilised white powder |
| Vial content | 10mg per vial |
| Purity | ≥99% HPLC |
| Identity | MS confirmed |
| Storage | −20°C lyophilised; 4°C reconstituted, use within 7 days |
| Reconstitution | Bacteriostatic water or 0.9% NaCl |
Certificate of Analysis (COA)
Frequently Asked Questions
Frequently asked questions
A seemingly elegant design can quickly begin to bloat with unexpected content or break under the weight of actual activity. Fake data can ensure a nice looking layout but it doesn’t reflect what a living, breathing application must endure. Real data does.
Websites in professional use templating systems. Commercial publishing platforms and content management systems ensure that you can show different text, different data using the same template. When it’s about controlling hundreds of articles, product pages for web shops.
A seemingly elegant design can quickly begin to bloat with unexpected content or break under the weight of actual activity. Fake data can ensure a nice looking layout but it doesn’t reflect what a living, breathing application must endure. Real data does.
Websites in professional use templating systems. Commercial publishing platforms and content management systems ensure that you can show different text, different data using the same template. When it’s about controlling hundreds of articles, product pages for web shops.
Reviews
Clear filtersThere are no reviews yet.