Lefuheal 20mg Tablets | 100-Count | LEFLUNOMIDE

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What is Lefuheal 20mg (LEFLUNOMIDE)?

DMARD for rheumatoid arthritis and psoriatic arthritis. Second-line after methotrexate failure or intolerance. Once-daily dosing due to long half-life of active metabolite.

How it Works

Prodrug converted to teriflunomide — inhibits DHODH, blocking de novo pyrimidine synthesis in proliferating T and B cells — reduces immune-mediated joint inflammation.

Quick Specs

Common Side Effects

Diarrhea (most common), nausea, hair loss (usually mild), rash, elevated liver enzymes, hypertension, peripheral neuropathy (rare).

Safety Warnings

⚠️ TERATOGENIC — pregnancy absolutely contraindicated. Accelerated elimination procedure (cholestyramine) required before pregnancy. Hepatotoxicity monitoring — especially combined with methotrexate.