PEG MGF 2mg | 10-Vial Kit | Pegylated Mechano Growth Factor | Long-Acting Muscle Repair Research
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PEG MGF 2mg | 10-Vial Kit — PEGylated IGF-1 Ec splice variant — polyethylene glycol modification extends native MGF half-life from minutes to days, enabling systemic rather than purely autocrine/paracrine delivery in research. ≥99% HPLC purity, MS confirmed, Janoshik COA. Research use only.
* The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgement of your healthcare professional.
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What is PEG-MGF??
PEG-MGF (Pegylated Mechano Growth Factor, CAS 88096-37-7) is the polyethylene glycol-conjugated form of native MGF (IGF-1 Ec splice variant). Molecular formula C121H200N42O39, MW ~2888 g/mol (core peptide). PEGylation extends the half-life from ~5-7 minutes (native MGF) to 48-72 hours, enabling systemic distribution and sustained satellite cell activation. PEG-MGF activates muscle stem cells via the IGF-1R/PI3K/Akt/mTOR axis, drives MyoD and myogenin gene expression, and stimulates myofiber regeneration and hypertrophy in preclinical models. Unlike native MGF’s highly localised short-lived paracrine action, PEG-MGF’s sustained circulation enables whole-body satellite cell activation from a single administration.
Research Applications
Satellite Cell Activation
Quiescent satellite cell recruitment, MyoD/myogenin upregulation, myoblast proliferation and fusion
Extended Pharmacokinetics
PEGylation T1/2 48-72h vs. native MGF 5 min – 2-3x/week dosing sufficient for sustained IGF-1R engagement
Muscle Hypertrophy & Repair
PI3K/Akt/mTOR pathway, mTORC1-driven protein synthesis, MRI-confirmed cross-sectional area increase in animal models
Sarcopenia & Wasting Models
Age-related satellite cell decline reversal, cachexia and denervation atrophy models, muscle mass restoration
Systemic vs. Local MGF Comparison
PEG-MGF systemic distribution vs. native MGF localised autocrine/paracrine action – receptor kinetics and tissue distribution
Quick Specs
| Form | Lyophilized powder |
| Purity | >=99% by HPLC – every batch |
| CAS Number | 88096-37-7 |
| Also Known As | PEG-IGF-1Ec, Pegylated MGF |
| Molecular Formula | C121H200N42O39 |
| Molecular Weight | ~2888 g/mol (core peptide) |
| Half-Life | 48-72h (vs. ~5 min native MGF) – PEG conjugation |
| Peptide Type | PEGylated IGF-1 splice variant / satellite cell activator – long-acting |
| Identity | MS molecular weight confirmed – every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS – Qingdao, China |
| Storage | -20C sealed | 2-8C reconstituted (2-4 weeks) |
| Shelf Life | 24 months unopened |
Certificate of Analysis (COA)
Frequently Asked Questions
Frequently asked questions
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A seemingly elegant design can quickly begin to bloat with unexpected content or break under the weight of actual activity. Fake data can ensure a nice looking layout but it doesn’t reflect what a living, breathing application must endure. Real data does.
Websites in professional use templating systems. Commercial publishing platforms and content management systems ensure that you can show different text, different data using the same template. When it’s about controlling hundreds of articles, product pages for web shops.
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