VIP 5mg | 20-Vial Kit | Vasoactive Intestinal Peptide | Neuropeptide & Anti-Inflammatory Research
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VIP 5mg | 20-Vial Kit — Vasoactive intestinal peptide — VPAC1/VPAC2 receptor-mediated neuropeptide studied for bronchodilation, immunomodulation, circadian rhythm regulation via SCN, and anti-inflammatory effects in GI and pulmonary research. ≥99% HPLC purity, MS confirmed, Janoshik COA. Research use only.
* The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgement of your healthcare professional.
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What is VIP??
VIP (Vasoactive Intestinal Peptide, CAS 37221-79-7) is a 28-amino acid neuropeptide hormone (His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂) first isolated from porcine intestine. Molecular formula C₁₄₇H₂₃₇N₄₃O₄₃S, MW 3326.78 g/mol. VIP acts at VPAC1 and VPAC2 receptors (Gs/cAMP) broadly expressed in CNS, lung, gut, immune cells, and vasculature. It is a potent smooth muscle relaxant, bronchodilator, immunomodulator, and circadian pacemaker peptide (via VPAC2 in the SCN) — making it one of the most pleiotropic neuropeptides in research.
Research Applications
VPAC1/VPAC2 Receptor Pharmacology
Gs/cAMP signalling, receptor selectivity profiling, VPAC1 vs. VPAC2 tissue distribution
Immunomodulation
Anti-inflammatory: IL-10/TGF-β induction, IL-6/TNF-α suppression, Treg promotion, macrophage M2 polarisation
Pulmonary Research
Bronchodilation, pulmonary hypertension, airway smooth muscle relaxation, inflammatory lung models
Circadian Biology
SCN VPAC2-mediated circadian pacemaking, VIP neuron interneuron synchronisation, phase-shift studies
GI & Vascular Research
Intestinal smooth muscle relaxation, splanchnic vasodilation, gut hormone secretion, colitis models
Quick Specs
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 37221-79-7 |
| Sequence | His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂ |
| Molecular Formula | C₁₄₇H₂₃₇N₄₃O₄₃S |
| Molecular Weight | 3326.78 g/mol |
| Receptors | VPAC1 (VIPR1) + VPAC2 (VIPR2) — Gs/cAMP coupled |
| Peptide Type | Endogenous 28-aa neuropeptide hormone / VPAC1/VPAC2 agonist |
| Identity | MS molecular weight confirmed — every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Storage | -20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Shelf Life | 24 months unopened |
Certificate of Analysis (COA)
Frequently Asked Questions
Frequently asked questions
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Websites in professional use templating systems. Commercial publishing platforms and content management systems ensure that you can show different text, different data using the same template. When it’s about controlling hundreds of articles, product pages for web shops.
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