AICAR 100mg | 10-Vial Kit | AMPK Activator | Metabolic & Exercise-Mimetic Research

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What is AICAR??

AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide, also known as Acadesine or AICA Ribonucleotide, CAS 2627-69-2) is a cell-permeable nucleoside analogue that is phosphorylated intracellularly to ZMP — a structural AMP mimic. Molecular formula C₉H₁₄N₄O₈P, MW 338.21 g/mol (free acid). ZMP directly activates AMP-activated protein kinase (AMPK) by allosterically mimicking a rise in cellular AMP:ATP ratio, without requiring actual energy depletion. As an exercise-mimetic compound, AICAR recapitulates key molecular adaptations of endurance exercise — upregulating GLUT4, stimulating fatty acid oxidation, inducing mitochondrial biogenesis via PGC-1α, and activating SIRT1. It is the gold-standard research tool for dissecting AMPK-dependent from AMPK-independent exercise signalling.

Research Applications

Quick Specs

Certificate of Analysis (COA)

Frequently Asked Questions