Dermorphin 10mg | 10-Vial Kit | Opioid Heptapeptide | High-Dose µ-Receptor Research
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Dermorphin 10mg | 10-Vial Kit — D-amino acid opioid heptapeptide — 500× higher μ-opioid receptor (MOR) affinity vs. morphine, studied for MOR pharmacology, receptor selectivity, and opioid peptide structure-activity research. ≥99% HPLC purity, MS confirmed, Janoshik COA. Research use only.
* The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgement of your healthcare professional.
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What is Dermorphin (High-Dose)??
Dermorphin (CAS 77614-16-5) is a naturally occurring heptapeptide opioid first isolated from the skin of South American frogs (Phyllomedusa sauvagei). Sequence: H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH₂. Molecular formula C₄₀H₅₀N₈O₁₀, MW 802.88 g/mol. This 10mg/vial high-dose format supports dose-escalation studies, multi-arm MOR pharmacology experiments, and long-duration in vivo analgesic paradigms requiring larger quantities. Dermorphin exhibits approximately 1,000-fold greater µ-opioid receptor (MOR) potency than morphine in preclinical binding assays, with high selectivity for MOR over δ and κ subtypes. The D-Ala² residue confers DPP-IV and protease resistance, extending half-life relative to linear endogenous opioids.
Research Applications
High-Dose MOR Pharmacology
Dose-escalation µ-opioid receptor occupancy, Gi/o signalling kinetics, receptor saturation profiling
Analgesic Dose-Response
Multi-arm hot-plate/tail-flick/formalin models across concentration range — morphine comparison
Tolerance & Sensitisation
Repeated high-dose MOR stimulation, receptor internalisation, GIRK channel desensitisation
β-Arrestin & Biased Agonism
β-arrestin-2 recruitment, ERK1/2 phosphorylation bias vs. G-protein signalling at elevated concentrations
D-Amino Acid Stability
DPP-IV resistance profiling — D-Ala² contribution to plasma and tissue half-life
Quick Specs
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 77614-16-5 |
| Sequence | H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH₂ |
| Molecular Formula | C₄₀H₅₀N₈O₁₀ |
| Molecular Weight | 802.88 g/mol |
| Peptide Type | Natural heptapeptide opioid / µ-MOR selective agonist — 10mg/vial high-dose |
| Identity | MS molecular weight confirmed — every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Storage | -20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Shelf Life | 24 months unopened |
Certificate of Analysis (COA)
Frequently Asked Questions
Frequently asked questions
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A seemingly elegant design can quickly begin to bloat with unexpected content or break under the weight of actual activity. Fake data can ensure a nice looking layout but it doesn’t reflect what a living, breathing application must endure. Real data does.
Websites in professional use templating systems. Commercial publishing platforms and content management systems ensure that you can show different text, different data using the same template. When it’s about controlling hundreds of articles, product pages for web shops.
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