Dihexa 5mg | 10-Vial Kit | HGF/MET Nootropic Peptide | Cognitive & Synaptogenic Research
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Dihexa 5mg | 10-Vial Kit — HGF/MET agonist heptapeptide (PNB-0408) — activates hepatocyte growth factor receptor to drive hippocampal synaptogenesis and dendritic spine density; studied for cognitive enhancement and memory improvement. ≥99% HPLC purity, MS confirmed, Janoshik COA. Research use only.
* The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgement of your healthcare professional.
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What is Dihexa??
Dihexa (PNB-0408, CAS 1239264-98-2) is a small peptidomimetic derived from angiotensin IV (Ang IV) that potentiates hepatocyte growth factor (HGF) signalling at the MET receptor. Molecular formula C₂₄H₃₉N₃O₄, MW 437.58 g/mol. Unlike classical nootropics, Dihexa operates by stabilising HGF–MET complexes, driving de novo synaptogenesis — the formation of new dendritic spines and synaptic connections — rather than simply modulating existing neurotransmitter systems. In preclinical studies it outperformed BDNF in spine density and was estimated to be 10⁷-fold more potent than BDNF at synaptogenesis. It is highly lipophilic and CNS-penetrant, active via sc, ip, and transdermal routes.
Research Applications
HGF/MET Synaptogenesis
HGF–MET complex stabilisation, dendritic spine formation, synaptic density quantification by microscopy
Cognitive Function
Morris Water Maze, radial arm maze, NOR — spatial memory and learning in aged/lesioned rodent models
Neurodegeneration Models
Scopolamine-induced amnesia, cholinergic lesion, Alzheimer’s-like transgenic model reversal
vs BDNF Potency Comparison
10⁷× BDNF potency at synaptogenesis — dose-response and receptor pathway comparison studies
Neuroplasticity & Repair
Post-stroke and TBI recovery, dendritic arborisation, long-term potentiation (LTP) modulation
Quick Specs
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 1239264-98-2 |
| Also Known As | PNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide |
| Molecular Formula | C₂₄H₃₉N₃O₄ |
| Molecular Weight | 437.58 g/mol |
| Mechanism | HGF/MET receptor complex potentiation → synaptogenesis |
| Identity | MS molecular weight confirmed — every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Storage | -20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Shelf Life | 24 months unopened |
Certificate of Analysis (COA)
Frequently Asked Questions
Frequently asked questions
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A seemingly elegant design can quickly begin to bloat with unexpected content or break under the weight of actual activity. Fake data can ensure a nice looking layout but it doesn’t reflect what a living, breathing application must endure. Real data does.
Websites in professional use templating systems. Commercial publishing platforms and content management systems ensure that you can show different text, different data using the same template. When it’s about controlling hundreds of articles, product pages for web shops.
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