GDF-8 (Myostatin) 1mg | 10-Vial Kit | Recombinant TGF-beta | Muscle Growth Inhibitor Research
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GDF-8 (Myostatin) 1mg | 10-Vial Kit — recombinant human myostatin, endogenous TGF-β superfamily member that limits skeletal muscle mass; used as research reference to characterise myostatin inhibition models and validate FST-344/ACE-031 effects. ≥99% HPLC purity, MS confirmed, Janoshik COA. Research use only.
$350.00
* The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgement of your healthcare professional.
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What is GDF-8 (Myostatin)??
GDF-8 (Growth Differentiation Factor 8, also known as Myostatin / MSTN, CAS 57103-13-4) is a member of the TGF-beta superfamily expressed specifically in developing and adult skeletal muscle. The bioactive form is a disulfide-linked homodimer (mature C-terminal domain, Asp268-Ser376) with an apparent MW of approximately 25 kDa. GDF-8 is the most potent endogenous negative regulator of skeletal muscle mass – signalling through ACVR2B/ActRIIB and ALK4/5 receptors to activate SMAD2/3 transcription factors, suppressing protein synthesis and promoting muscle atrophy. Loss-of-function mutations cause dramatic muscle hypertrophy across mammals (Belgian Blue cattle, whippet dogs, rare human cases). Recombinant GDF-8 enables positive-control muscle inhibition assays, inhibitor/neutraliser screening (ACE-031, follistatin, anti-MSTN antibodies), and mechanistic TGF-beta pathway dissection.
Research Applications
Muscle Inhibition Positive Control
SMAD2/3 signalling activation, myoblast differentiation inhibition, atrophy gene expression – positive control for myostatin inhibitor screening
Receptor Binding & Signalling
ACVR2B/ALK4/5 complex formation, SMAD2/3 phosphorylation kinetics, receptor selectivity vs. GDF-11, activins, BMPs
Inhibitor Screening Assays
Neutralisation potency of ACE-031, follistatin, anti-MSTN antibodies, SMAD pathway antagonists – ED50 determination
Muscle Wasting Models
Cachexia, sarcopenia, denervation atrophy – exogenous GDF-8 dose-response to establish atrophy gradient
Bone & Adipose Cross-Talk
Myostatin effects on osteoprogenitor differentiation, bone density, adipogenesis – body composition multi-tissue studies
Quick Specs
| Form | Lyophilized powder |
| Purity | >=99% by HPLC – every batch |
| CAS Number | 57103-13-4 |
| Also Known As | Myostatin, MSTN, GDF8 |
| Active Domain | Mature C-terminal homodimer, Asp268-Ser376 – 109 aa per monomer |
| Molecular Weight | ~25 kDa (active homodimer) | ~12 kDa (monomer under reducing SDS-PAGE) |
| Receptors | ACVR2B (ActRIIB) / ALK4/ALK5 – SMAD2/3 signalling |
| Peptide Type | Recombinant TGF-beta superfamily member / endogenous muscle growth inhibitor |
| Identity | MS molecular weight confirmed – every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS – Qingdao, China |
| Storage | -20C sealed | 2-8C reconstituted (use within 2 weeks) |
| Shelf Life | 24 months unopened |
Certificate of Analysis (COA)
Frequently Asked Questions
Frequently asked questions
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Websites in professional use templating systems. Commercial publishing platforms and content management systems ensure that you can show different text, different data using the same template. When it’s about controlling hundreds of articles, product pages for web shops.
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