Orexin A 10mg | 10-Vial Kit | Hypocretin-1 | Wakefulness & Narcolepsy Research
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Orexin A 10mg | 10-Vial Kit — Orexin-A (Hypocretin-1) — 33aa neuropeptide with two disulfide bridges activating OX1R/OX2R to regulate wakefulness, arousal, and appetite; studied in narcolepsy and metabolic models. ≥99% HPLC purity, MS confirmed, Janoshik COA. Research use only.
* The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgement of your healthcare professional.
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What is Orexin A??
Orexin A (Hypocretin-1, CAS 205599-75-3) is a 33-amino acid hypothalamic neuropeptide produced from prepro-orexin by enzymatic cleavage. It has an N-terminal pyroglutamyl residue, two intramolecular disulfide bridges (Cys6-Cys12, Cys7-Cys14), and C-terminal amidation. MW 3562.14 g/mol. Orexin A is produced exclusively in a small population (~50,000-80,000) of lateral hypothalamic neurons and projects widely through the CNS. It binds both OX1R and OX2R receptors (Gq-coupled) with approximately equal high affinity – activating arousal circuits involving norepinephrine (locus coeruleus), dopamine, histamine, and acetylcholine systems. Loss of orexin-producing neurons causes narcolepsy type 1 – the definitive disease model for the orexin system. Orexin A also modulates feeding behaviour, reward/motivation, stress responses, and energy homeostasis.
Research Applications
Sleep/Wake & Arousal Research
OX1R/OX2R-mediated wakefulness stabilisation, narcolepsy/cataplexy models, hypocretin neuron ablation studies
Narcolepsy Models
Orexin deficiency rescue in orexin knockout mice, ICV administration cognitive restoration in sleep-deprived primates
Appetite & Feeding Behaviour
Orexigenic signalling, lateral hypothalamic feeding circuits, NPY/orexin interaction, fasting-induced prepro-orexin upregulation
Reward & Addiction
OX1R role in drug-seeking, reward salience, cocaine/opioid cue-induced reinstatement models
Energy Homeostasis
Glucose-sensing orexin neurons, tandem pore K+ channel glucose inhibition, OX2R feeding and adiposity regulation
Quick Specs
| Form | Lyophilized powder |
| Purity | >=99% by HPLC – every batch |
| CAS Number | 205599-75-3 |
| Also Known As | Hypocretin-1, HCRT1 |
| Sequence | pGlu-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 [Cys6-Cys12, Cys7-Cys14] |
| Molecular Weight | 3562.14 g/mol |
| Receptors | OX1R + OX2R – equal high affinity (vs. Orexin B selective OX2R) |
| Peptide Type | Endogenous 33-aa hypothalamic neuropeptide / dual OX1R/OX2R agonist |
| Identity | MS molecular weight confirmed – every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS – Qingdao, China |
| Storage | -20C sealed | 2-8C reconstituted (2-4 weeks) |
| Shelf Life | 24 months unopened |
Certificate of Analysis (COA)
Frequently Asked Questions
Frequently asked questions
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Websites in professional use templating systems. Commercial publishing platforms and content management systems ensure that you can show different text, different data using the same template. When it’s about controlling hundreds of articles, product pages for web shops.
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